Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment

Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment

Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated tumor cells have been demonstrated to be a promising immunotherapy for solid tumors. We focused on sole injection of tumor cells that were inactivated by HHP and their combination with local radiotherapy (RTx)...

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Bibliographic Details
Main Authors: Christoph Seitz, Michael Rückert, Lisa Deloch, Eva-Maria Weiss, Sebastian Utz, Marika Izydor, Nina Ebel, Eberhard Schlücker, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
radiotherapy
immunotherapy
tumor cell-based vaccine
high hydrostatic pressure
malignant melanoma
colorectal carcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00805/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00805/full

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