Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. Our previous results demonstrated that inactivated influenza vaccine (IIV) facilitates hippocampal neurogenesis and blocks lipopolysaccharide (LPS)-induced cognitive i...

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Bibliographic Details
Main Authors: Yunjie Yang, Zitian He, Zhiwei Xing, Zejie Zuo, Lifang Yuan, Yingying Wu, Mei Jiang, Fangfang Qi, Zhibin Yao
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Influenza vaccine
Alzheimer’s disease
β-Amyloid
Regulatory T cells
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01741-4

Internet

http://link.springer.com/article/10.1186/s12974-020-01741-4

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