Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone.

Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone.

Missense mutations of the GJA1 gene encoding the gap junction channel protein connexin43 (Cx43) cause bone malformations resulting in oculodentodigital dysplasia (ODDD), while GJA1 null and ODDD mutant mice develop osteopenia. In this study we investigated Cx43 expression and channel functions in gi...

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Bibliographic Details
Main Authors: Peter Balla, Mate Elod Maros, Gabor Barna, Imre Antal, Gergo Papp, Zoltan Sapi, Nicholas Anthony Athanasou, Maria Serena Benassi, Pierro Picci, Tibor Krenacs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125316

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https://doi.org/10.1371/journal.pone.0125316

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