A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli

A Comprehensive Proteomic and Phosphoproteomic Analysis of Retinal Pigment Epithelium Reveals Multiple Pathway Alterations in Response to the Inflammatory Stimuli

Overwhelming and persistent inflammation of retinal pigment epithelium (RPE) induces destructive changes in the retinal environment. However, the precise mechanisms remain unclear. In this study, we aimed to investigate RPE-specific biological and metabolic responses against intense inflammation and...

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Bibliographic Details
Main Authors: Juha Song, Dohyun Han, Heonyi Lee, Da Jung Kim, Joo-Youn Cho, Jae-Hak Park, Seung Hyeok Seok
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
ARPE-19
inflammation
lipopolysaccharide (LPS)
proteomics
phosphoproteomics
tandem-mass tags (TMTs)
Online Access:https://www.mdpi.com/1422-0067/21/9/3037

Internet

https://www.mdpi.com/1422-0067/21/9/3037

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