P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus

P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus

Introduction: P2X7R is an extracellular ATP-gated receptor involved in inflammatory and autoimmune processes mainly acting through NLPR3-inflammasome activation and IL-1β release, also implicated in lymphocyte proliferation and cellular apoptosis. Several observations from animal models and patients...

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Bibliographic Details
Main Authors: Federica Furini, Anna Lisa Giuliani, Mattia Erminio Parlati, Marcello Govoni, Francesco Di Virgilio, Alessandra Bortoluzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
P2X7R
Systemic Lupus Erythematosus
NLRP3 inflammasome
IL-1β
IL-6
serositis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00435/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00435/full

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