Isoforskolin Alleviates AECOPD by Improving Pulmonary Function and Attenuating Inflammation Which Involves Downregulation of Th17/IL-17A and NF-κB/NLRP3

Isoforskolin Alleviates AECOPD by Improving Pulmonary Function and Attenuating Inflammation Which Involves Downregulation of Th17/IL-17A and NF-κB/NLRP3

Chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide, is widely considered to be related to cigarette smoke (CS), and viral infections trigger acute exacerbation of COPD (AECOPD). Isoforskolin (ISOF) is a bioactive component from the plant Coleus forskohli...

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Bibliographic Details
Main Authors: Chuang Xiao, Sha Cheng, Runfeng Li, Yutao Wang, Deyou Zeng, Haiming Jiang, Yaping Liang, Rong Huang, Hanxiao Pan, Xiao Wu, Yan Fang, Chen Chen, Xian Li, Rongping Zhang, Xinhua Wang, Zifeng Yang, Weimin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
AECOPD
isoforskolin
pulmonary function
Th17 cell
NF-κB
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.721273/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.721273/full

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