Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation

Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation

Background: The function of H3F3A G43W mutation, which has been observed in almost all GCTB, remains poorly characterized. Breakthrough in malignant GCTB has been trapped by the lack of clinical available drugs, limited canonical patient samples and paucity of fidelity preclinical models. Methods: T...

Full description

Bibliographic Details
Main Authors: Jiang Yafei, Mu Haoran, Jiang Wenyan, Xue Linghang, Tian Kai, Wang Gangyang, Wang Zhuoying, Han Jing, Yang Mengkai, Tang Yujie, Hua Yingqi, Cai Zhengdong
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Malignant giant cell tumor of bone
Drug screening
Patient-derived xenograft
Histone deacetylase inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X21000267

Internet

http://www.sciencedirect.com/science/article/pii/S2214031X21000267

Similar Items