Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models

Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models

The main purpose of this study is to explore sex differences in the antidepressant effect of sertraline in genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene mouse models in the forced swim test (FST). Our results demonstrated a significant reduction of depression-li...

Full description

Bibliographic Details
Main Authors: Lei Ma, Yong Xu, Wei Jiang, Yuhong Li, Xinzhu Zhang, Gang Wang, Rena Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
sex difference
sertraline
5-HT
DA
estrogen
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00024/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00024/full

Similar Items