Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice

Salubrinal improves mechanical properties of the femur in osteogenesis imperfecta mice

Salubrinal is an agent that reduces the stress to the endoplasmic reticulum by inhibiting de-phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). We and others have previously shown that the elevated phosphorylation of eIF2α stimulates bone formation and attenuates bone resor...

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Bibliographic Details
Main Authors: Shinya Takigawa, Brian Frondorf, Shengzhi Liu, Yang Liu, Baiyan Li, Akihiro Sudo, Joseph M. Wallace, Hiroki Yokota, Kazunori Hamamura
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Salubrinal
Osteogenesis imperfecta
Osteoclasts
Bone marrow derived cells
Mechanical test
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301311

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http://www.sciencedirect.com/science/article/pii/S1347861316301311

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