Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

BackgroundEmerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrated that sphingosine-1-phosphate (S1P), the product...

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Bibliographic Details
Main Authors: Seok-Woo Hong, Jinmi Lee, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Format: Article
Language:English
Published: Academya Publishing Co. 2018-09-01
Series:Endocrinology and Metabolism
Subjects:
Sphingosine 1-phosphate
Sphingosine kinase
Insulin-secreting cells
Mitochondria
Prohibitin
Online Access:https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-403.pdf

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https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-403.pdf

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