Absence of AKT1 mutations in glioblastoma.

Absence of AKT1 mutations in glioblastoma.

<h4>Background</h4>Oncogenic activation of the PI3K signalling pathway plays a pivotal role in the development of glioblastoma multiforme (GBM). A central node in PI3K downstream signalling is controlled by the serine-threonine kinase AKT1. A somatic mutation affecting residue E17 of the...

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Bibliographic Details
Main Authors: Fonnet E Bleeker, Simona Lamba, Carlo Zanon, Angela A van Tilborg, Sieger Leenstra, Dirk Troost, Theo Hulsebos, W Peter Vandertop, Alberto Bardelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19461960/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19461960/pdf/?tool=EBI

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