Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis

Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis

Abstract Background The thymus plays an essential role in the pathogenesis of myasthenia gravis (MG). In patients with MG, natural regulatory T cells (nTreg), a subpopulation of T cells that maintain tolerance to self-antigens, are severely impaired in the thymuses. In our previous study, upregulate...

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Bibliographic Details
Main Authors: Peng Zhang, Ru-Tao Liu, Tong Du, Chun-Lin Yang, Yu-Dong Liu, Meng-Ru Ge, Min Zhang, Xiao-Li Li, Heng Li, Ying-Chun Dou, Rui-Sheng Duan
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Exosomes
Thymus
Experimental autoimmune myasthenia gravis (EAMG)
Foxp3+ natural regulatory T cells
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Online Access:http://link.springer.com/article/10.1186/s12974-019-1587-0

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http://link.springer.com/article/10.1186/s12974-019-1587-0

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