Does Pioglitazone Lead to Neutrophil Extracellular Traps Formation in Chronic Granulomatous Disease Patients?

Does Pioglitazone Lead to Neutrophil Extracellular Traps Formation in Chronic Granulomatous Disease Patients?

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, the enzyme complex responsible for reactive oxygen species (ROS) production, is defective in chronic granulomatous disease (CGD) patients. This enzyme helps in antimicrobial host defense by phagocytes. CGD patients are unable to form neutr...

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Bibliographic Details
Main Authors: Gouri P. Hule, Umair Ahmed Bargir, Manasi Kulkarni, Priyanka Kambli, Prasad Taur, Mukesh Desai, Manisha Rajan Madkaikar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
peroxisome proliferator-activated receptor gamma agonists
pioglitazone
chronic granulomatous disease
neutrophil extracellular traps
reactive oxygen species
mitochondrial ROS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01739/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01739/full

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