Luteolin attenuates oxidative stress in mice with cerebral ischemia-reperfusion by inhibiting Drp1 activation and promoting autophagy flux

Luteolin attenuates oxidative stress in mice with cerebral ischemia-reperfusion by inhibiting Drp1 activation and promoting autophagy flux

Objective To explore the mechanism by which luteolin alleviates oxidative stress in mice with cerebral ischemia-reperfusion. Methods We screened the antioxidants with potential therapeutic effect on cerebral ischemia-reperfusion injury using CMap dataset based on their targeted drug scores and veri...

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Bibliographic Details
Main Authors: ZENG Xue, WANG Long, LAI Yujie, CHEN Bo, JIANG Hang
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2020-09-01
Series:Di-san junyi daxue xuebao
Subjects:
luteolin
cerebral ischemia-reperfusion
mitochondria
reactive oxygen species
drp1
autophagy flux
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/202004273.htm

Internet

http://aammt.tmmu.edu.cn/Upload/rhtml/202004273.htm

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