Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specifi...

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Bibliographic Details
Main Authors: Jonathan Mowers, Maeran Uhm, Shannon M Reilly, Joshua Simon, Dara Leto, Shian-Huey Chiang, Louise Chang, Alan R Saltiel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-12-01
Series:eLife
Subjects:
inflammation
obesity
energy expenditure
catecholamine resistance
Online Access:https://elifesciences.org/articles/01119

Internet

https://elifesciences.org/articles/01119

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