Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling

Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling

Summary: Rac1 is a small RhoGTPase switch that orchestrates actin branching in space and time and protrusion/retraction cycles of the lamellipodia at the cell front during mesenchymal migration. Biosensor imaging has revealed a graded concentration of active GTP-loaded Rac1 in protruding regions of...

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Bibliographic Details
Main Authors: Amanda Remorino, Simon De Beco, Fanny Cayrac, Fahima Di Federico, Gaetan Cornilleau, Alexis Gautreau, Maria Carla Parrini, Jean-Baptiste Masson, Maxime Dahan, Mathieu Coppey
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315322

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http://www.sciencedirect.com/science/article/pii/S2211124717315322

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