Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling.

BACKGROUND:Remodeling of cardiac repolarizing currents, such as the downregulation of slowly activating K+ channels (IKs), could underlie ventricular fibrillation (VF) in heart failure (HF). We evaluated the role of Iks remodeling in VF susceptibility using a tachypacing HF model of transgenic rabbi...

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Bibliographic Details
Main Authors: Emily Lau, Konstantinos Kossidas, Tae Yun Kim, Yukiko Kunitomo, Ohad Ziv, Zhen Song, Chantel Taylor, Lorraine Schofield, Joe Yammine, Gongxin Liu, Xuwen Peng, Zhilin Qu, Gideon Koren, Bum-Rak Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4430457?pdf=render

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http://europepmc.org/articles/PMC4430457?pdf=render

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