Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog Signaling

Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog Signaling

Platinum-based regimens have been routinely used in the clinical treatment of patients with esophageal squamous cell carcinoma (ESCC). However, administration of these drugs is frequently accompanied by drug resistance. Revealing the underlying mechanisms of the drug resistance and developing agents...

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Bibliographic Details
Main Authors: Wei Cui, Tingting Fang, Zhaoheng Duan, Dongfang Xiang, Yanxia Wang, Mengsi Zhang, Fangzheng Zhai, Xiang Cui, Lang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cisplatin resistance
esophageal squamous cell carcinoma
Shh pathway
dihydroartemisinin
cancer stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.596788/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.596788/full

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