Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Accurate annotation of protein coding regions is essential for understanding how genetic information is translated into function. We describe riboHMM, a new method that uses ribosome footprint data to accurately infer translated sequences. Applying riboHMM to human lymphoblastoid cell lines, we iden...

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Bibliographic Details
Main Authors: Anil Raj, Sidney H Wang, Heejung Shim, Arbel Harpak, Yang I Li, Brett Engelmann, Matthew Stephens, Yoav Gilad, Jonathan K Pritchard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
ribosome profiling
translation
hidden Markov models
upstream ORF
noncoding RNA
Online Access:https://elifesciences.org/articles/13328

Internet

https://elifesciences.org/articles/13328

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