Ablation of Survivin in T Cells Attenuates Acute Allograft Rejection after Murine Heterotopic Heart Transplantation by Inducing Apoptosis

Ablation of Survivin in T Cells Attenuates Acute Allograft Rejection after Murine Heterotopic Heart Transplantation by Inducing Apoptosis

Although studies in oncology have well explored the pharmacological effects of Birc5, little is known about its role in allogeneic T-cell responses. Therefore, the present study used a mouse model of acute heart allograft rejection to investigate the protective effect and mechanism of conditional kn...

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Bibliographic Details
Main Authors: Heng Xu, Jizhang Yu, Jikai Cui, Zhang Chen, Xi Zhang, Yanqiang Zou, Yifan Du, Yuan Li, Sheng Le, Lang Jiang, Jiahong Xia, Jie Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
transplantation immunology
survivin
Birc5
T cell
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.710904/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.710904/full

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