Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors

Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within Neurons by Small-Molecule, Non-Peptidic Inhibitors

Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associated protein of 25kDa (SNAP-25), is particularly l...

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Bibliographic Details
Main Authors: Sina Bavari, Cary J. Retterer, Edna Torres-Melendez, Sarah J. Sandwick, Laura M. Wanner, Lyal E. Tressler, Jonathan E. Nuss, Gordon Ruthel, James C. Burnett
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Toxins
Subjects:
botulinum neurotoxin
small molecule non-peptidic inhibitor
neutralizing antibody
Bafilomycin A1
Online Access:http://www.mdpi.com/2072-6651/3/3/207/

Internet

http://www.mdpi.com/2072-6651/3/3/207/

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