In silico Description of LAT1 Transport Mechanism at an Atomistic Level

In silico Description of LAT1 Transport Mechanism at an Atomistic Level

The molecular mechanism of transport mediated by LAT1, a sodium-independent antiporter of large neutral amino acids, was investigated through in silico procedures, specifically making reference to two transported substrates, tyrosine (Tyr) and leucine methyl ester (LME), and to 3,5-diiodo-L-tyrosine...

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Bibliographic Details
Main Authors: Luca Palazzolo, Chiara Parravicini, Tommaso Laurenzi, Uliano Guerrini, Cesare Indiveri, Elisabetta Gianazza, Ivano Eberini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Chemistry
Subjects:
LAT1
targeted molecular dynamic
aminoacid transporters
tyrosine
molecular docking
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00350/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00350/full

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