MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients

MiR-21, miR-34a, miR-125b, miR-181d and miR-648 levels inversely correlate with MGMT and TP53 expression in primary glioblastoma patients

Introduction: TP53 and MGMT alterations play a crucial role in glioblastoma (GB) pathogenesis. TP53 and MGMT function is affected by several pathologic mechanisms, such as point mutations or promoter methylation, which are well characterized. Expression of both genes can be regulated by other mech...

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Bibliographic Details
Main Authors: Dorota Jesionek-Kupnicka, Marcin Braun, Berenika Trąbska-Kluch, Joanna Czech, Małgorzata Szybka, Bożena Szymańska, Dominika Kulczycka-Wojdala, Michał Bieńkowski, Radzisław Kordek, Izabela Zawlik
Format: Article
Language:English
Published: Termedia Publishing House 2017-07-01
Series:Archives of Medical Science
Subjects:
gb
mgmt
tp53
o6-methylguanine-dna methyltransferase
microrna
Online Access:https://www.termedia.pl/MiR-21-miR-34a-miR-125b-miR-181d-and-miR-648-levels-inversely-correlate-with-MGMT-and-TP53-expression-in-primary-glioblastoma-patients,19,30454,1,1.html

Internet

https://www.termedia.pl/MiR-21-miR-34a-miR-125b-miR-181d-and-miR-648-levels-inversely-correlate-with-MGMT-and-TP53-expression-in-primary-glioblastoma-patients,19,30454,1,1.html

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