Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

Angiopoietin-2 (ANG2/ANGPT2) is a context-dependent TIE2 receptor agonist/antagonist and proangiogenic factor. Although ANG2 neutralization improves tumor angiogenesis and growth inhibition by vascular endothelial growth factor (VEGF)-A signaling blockade, the mechanistic underpinnings of such thera...

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Bibliographic Details
Main Authors: Nicolò Rigamonti, Ece Kadioglu, Ioanna Keklikoglou, Céline Wyser Rmili, Ching Ching Leow, Michele De Palma
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005610

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http://www.sciencedirect.com/science/article/pii/S2211124714005610

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