The impact of pre-existing HLA and red blood cell antibodies on transfusion support and engraftment in sickle cell disease after nonmyeloablative hematopoietic stem cell transplantation from HLA-matched sibling donors: A prospective, single-center, observational study

The impact of pre-existing HLA and red blood cell antibodies on transfusion support and engraftment in sickle cell disease after nonmyeloablative hematopoietic stem cell transplantation from HLA-matched sibling donors: A prospective, single-center, observational study

Background: Hematopoietic stem cell transplantation (HSCT) is curative for patients with sickle cell disease (SCD). Prior to HSCT, patients with SCD commonly receive RBC transfusions with some becoming RBC or HLA alloimmunized. This alloimmunization may impact post-HSCT transfusion requirements and...

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Bibliographic Details
Main Authors: Robert Sheppard Nickel, Willy A. Flegel, Sharon D. Adams, Jeanne E. Hendrickson, Hua Liang, John F. Tisdale, Matthew M. Hsieh
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:EClinicalMedicine
Subjects:
Alloimmunization
HLA antibody
Bone marrow transplant
Transfusion
Sickle cell disease
Chimerism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537020301760

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http://www.sciencedirect.com/science/article/pii/S2589537020301760

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