Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1

Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1

Serine protease Omi/HtrA2, a member of the HtrA family, is closely related to the maintenance of mitochondrial integrity and participates in apoptosis but its role in cerebral ischemia/reperfusion (I/R) injury and cellular oxidative stress response remains unclear. In this study, we found that I/R i...

Full description

Bibliographic Details
Main Authors: Hailong You, Yao Jin, Jinsong Kang, Ying Mao, Jing Su, Liankun Sun, Li Wang, Hao Meng
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Bioengineered
Subjects:
brain ischemia
mitochondrial
omi/htra2
oxidative stress
reperfusion injury
Online Access:http://dx.doi.org/10.1080/21655979.2020.1822105

Internet

http://dx.doi.org/10.1080/21655979.2020.1822105

Similar Items