Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds posse...

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Bibliographic Details
Main Authors: AleÅ¡ Obreza, Slavko PeÄÂar, Stanislav Gobec, Didier Blanot, Andreja KovaÄÂ, Rok Frlan
Format: Article
Language:English
Published: MDPI AG 2008-01-01
Series:Molecules
Subjects:
MurC
MurD
amidobenzaldehyde
inhibitors
antibacterial
hydrazide.
Online Access:http://www.mdpi.com/1420-3049/13/1/11/

Internet

http://www.mdpi.com/1420-3049/13/1/11/

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