Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage

BackgroundEmerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction, an early marker for atherosclerosis. In addi...

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Bibliographic Details
Main Authors: Raghda Ramadan, Els Vromans, Dornatien Chuo Anang, Ines Goetschalckx, Delphine Hoorelbeke, Elke Decrock, Sarah Baatout, Luc Leybaert, An Aerts
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
endothelial damage
ionizing radiation
connexin43 hemichannels
TAT-Gap19
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00212/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00212/full

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