Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 proteinopathy we found significant alterations in glucose metabolism including increased pyruvate, suggesting that modulating glycol...

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Bibliographic Details
Main Authors: Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G O'Conner, Jordan M Barrows, Alexander Starr, Tina Kovalik, Benjamin E Rabichow, Erik M Lehmkuhl, Dakotah D Shreiner, Archi Joardar, Jean-Charles Liévens, Robert Bowser, Rita Sattler, Daniela C Zarnescu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
human
drosophila
iPSC
Online Access:https://elifesciences.org/articles/45114

Internet

https://elifesciences.org/articles/45114

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