Apoptosis of Limb Innervating Motor Neurons and Erosion of Motor Pool Identity upon Lineage Specific Dicer Inactivation

Diversification of mammalian spinal motor neurons into hundreds of subtypes is critical for the maintenance of body posture and coordination of complex movements. Motor neuron differentiation is controlled by extrinsic signals that regulate intrinsic genetic programs specifying and consolidating mot...

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Bibliographic Details
Main Authors: Jun-An eChen, Hynek eWichterle
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00069/full