Cx43 Present at the Leading Edge Membrane Governs Promigratory Effects of Osteoblast-Conditioned Medium on Human Prostate Cancer Cells in the Context of Bone Metastasis

Cx43 Present at the Leading Edge Membrane Governs Promigratory Effects of Osteoblast-Conditioned Medium on Human Prostate Cancer Cells in the Context of Bone Metastasis

Among the different interacting molecules implicated in bone metastases, connexin43 (Cx43) may increase sensitivity of prostate cancer (PCa) cells to bone microenvironment, as suggested by our in silico and human tissue samples analyses that revealed increased level of Cx43 expression with PCa progr...

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Bibliographic Details
Main Authors: Jonathan Boucher, Annie-Claire Balandre, Marjolaine Debant, Justine Vix, Thomas Harnois, Nicolas Bourmeyster, Elodie Péraudeau, Amandine Chépied, Jonathan Clarhaut, Françoise Debiais, Arnaud Monvoisin, Laurent Cronier
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Cx43
prostate cancer
migration
gap junctions
bone metastasis
conditioned medium
Online Access:https://www.mdpi.com/2072-6694/12/10/3013

Internet

https://www.mdpi.com/2072-6694/12/10/3013

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