The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures

Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the pre-synaptic and inhibitory metabotropic glutamate receptor type 7 (mGlu7) reduces spontaneous seizures.We tested LSP2-9166, a recently devel...

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Bibliographic Details
Main Authors: Benoit Girard, Pola Tuduri, Maria Paula Moreno, Sophie Sakkaki, Cedric Barboux, Tristan Bouschet, Annie Varrault, Jihane Vitre, Isabelle McCort-Tranchepain, Julien Dairou, Francine Acher, Laurent Fagni, Nicola Marchi, Julie Perroy, Federica Bertaso
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Neuropharmacology
Metabotropic glutamate receptor
Animal models
Seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301056

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http://www.sciencedirect.com/science/article/pii/S0969996119301056

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