Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses

Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses

Mitochondria modulate cellular calcium homeostasis by the combined action of the mitochondrial calcium uniporter (MCU), a selective calcium entry channel, and the sodium calcium exchanger (NCLX), which extrudes calcium from mitochondria. In this study, we investigated MCU and NCLX in noise-induced h...

Full description

Bibliographic Details
Main Authors: Xianren Wang, Yuanping Zhu, Haishan Long, Song Pan, Hao Xiong, Qiaojun Fang, Kayla Hill, Ruosha Lai, Hu Yuan, Su-Hua Sha
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mitochondrial calcium uniporter (MCU)
sensory hair cell
ribbon synapses
noise-exposure
auditory threshold shifts
mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00469/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00469/full

Similar Items