Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis

Dependency of B-1 Cells in the Maintenance of Splenic Interleukin-10 Producing Cells and Impairment of Macrophage Resistance in Visceral Leishmaniasis

Visceral leishmaniasis is a neglected disease caused by Leishmania protozoa parasites transmitted by infected sand fly vectors. This disease represents the second in mortality among tropical infections and is associated to a profound immunosuppression state of the host. The hallmark of this infectio...

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Bibliographic Details
Main Authors: Angélica Fernandes Arcanjo, Dirlei Nico, Gabriellen Menezes Migliani de Castro, Yasmin da Silva Fontes, Paula Saltarelli, Debora Decote-Ricardo, Marise P. Nunes, Antônio Ferreira-Pereira, Clarisa B. Palatnik-de-Sousa, Célio G. Freire-de-Lima, Alexandre Morrot
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Microbiology
Subjects:
visceral leishmaniasis
Leishmania (L.) infantum chagasi
B-1 cells
host protective responses
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00978/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00978/full

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