The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association

The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association

Human hepatic lipase (hHL) mainly exists cell surface bound, whereas mouse HL (mHL) circulates in the blood stream. Studies have suggested that the carboxyl terminus of HL mediates cell surface binding. We prepared recombinant hHL, mHL, and chimeric proteins (hHLmt and mHLht) in which the carboxyl t...

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Bibliographic Details
Main Authors: Robert J. Brown, Joshua R. Schultz, Kerry W.S. Ko, John S. Hill, Tanya A. Ramsamy, Ann L. White, Daniel L. Sparks, Zemin Yao
Format: Article
Language:English
Published: Elsevier 2003-07-01
Series:Journal of Lipid Research
Subjects:
lipolysis
heparin
heparin binding domain
heparan sulfate proteoglycan
tributyrin
triolein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310920

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http://www.sciencedirect.com/science/article/pii/S0022227520310920

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