Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair
Abstract SOSS1 is a single-stranded DNA (ssDNA)-binding protein complex that plays a critical role in double-strand DNA break (DSB) repair. SOSS1 consists of three subunits: INTS3, SOSSC, and hSSB1, with INTS3 serving as a scaffold to stabilize this complex. Moreover, the integrator complex subunit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-08-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-021-00283-0 |