Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. In contrast, six different human E2 and E3 enzyme activities, including Cdc34 ort...

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Bibliographic Details
Main Authors: Spencer Hill, Kurt Reichermeier, Daniel C Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moradian, Michael J Sweredoski, Nora Caberoy, Brenda A Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
ubiquitin
ubiquitin-conjugating enzyme
ubiquitin ligases
cullin-RING ligase
protein degradation
Online Access:https://elifesciences.org/articles/51163

Internet

https://elifesciences.org/articles/51163

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