Gene Expression Profiles Reveal Extracellular Matrix and Inflammatory Signaling in Radiation-Induced Premature Differentiation of Human Fibroblast in vitro

Gene Expression Profiles Reveal Extracellular Matrix and Inflammatory Signaling in Radiation-Induced Premature Differentiation of Human Fibroblast in vitro

PurposeFibroblasts are considered to play a major role in the development of fibrotic reaction after radiotherapy and premature radiation-induced differentiation has been proposed as a cellular basis. The purpose was to relate gene expression profiles to radiation-induced phenotypic changes of human...

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Bibliographic Details
Main Authors: Carsten Herskind, Carsten Sticht, Ahmad Sami, Frank A. Giordano, Frederik Wenz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
fibroblast differentiation
extracellular matrix
radiation-induced fibrosis of the skin
inflammatory signaling
cell cycle-related genes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.539893/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.539893/full

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