ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.

ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.

BACKGROUND: Obesity is a multifactorial disease that arises from complex interactions between genetic predisposition and environmental factors. Leptin is central to the regulation of energy metabolism and control of body weight in mammals. METHODOLOGY/PRINCIPAL FINDINGS: To better recapitulate the c...

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Main Authors: Chen-Jee Hong, Pei-Jane Tsai, Chih-Ya Cheng, Chuan-Kai Chou, Huei-Fen Jheng, You-Chung Chuang, Chia-Ning Yang, Ya-Tzu Lin, Chih-Wei Hsu, Irene H Cheng, Shiow-Yi Chen, Shih-Jen Tsai, Ying-Jay Liou, Yau-Sheng Tsai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3000341?pdf=render

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http://europepmc.org/articles/PMC3000341?pdf=render

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