Genome-Based Analyses of Fitness Effects and Compensatory Changes Associated with Acquisition of <i>bla</i><sub>CMY</sub>-, <i>bla</i><sub>CTX-M</sub>-, and <i>bla</i><sub>OXA-48/VIM-1</sub>-Containing Plasmids in <i>Escherichia coli</i>

Genome-Based Analyses of Fitness Effects and Compensatory Changes Associated with Acquisition of <i>bla</i><sub>CMY</sub>-, <i>bla</i><sub>CTX-M</sub>-, and <i>bla</i><sub>OXA-48/VIM-1</sub>-Containing Plasmids in <i>Escherichia coli</i>

(1) Background: Resistance plasmids are under selective conditions beneficial for the bacterial host, but in the absence of selective pressure, this carriage may cause fitness costs. Compensation of this fitness burden is important to obtain competitive ability under antibiotic-free conditions. In t...

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Bibliographic Details
Main Authors: Michael Pietsch, Yvonne Pfeifer, Stephan Fuchs, Guido Werner
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antibiotics
Subjects:
AmpC
ESBL
carbapenemase
fitness burden
compensatory mutation
Online Access:https://www.mdpi.com/2079-6382/10/1/90

Internet

https://www.mdpi.com/2079-6382/10/1/90

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