Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle

Cycles of ischemia-reperfusion (IR) that occur during peripheral arterial disease (PAD) are associated with significant morbi-mortality, and aging is an irreversible risk factor of PAD. However, the effects of advanced age on IR-induced skeletal muscle mitochondrial dysfunction are not well known. Y...

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Bibliographic Details
Main Authors: Stéphanie Paradis, Anne-Laure Charles, Isabelle Georg, Fabienne Goupilleau, Alain Meyer, Michel Kindo, Gilles Laverny, Daniel Metzger, Bernard Geny
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Antioxidants
Subjects:
peripheral arterial disease
ischemia-reperfusion
skeletal muscle
mitochondria
respiration
calcium
oxidative stress
reactive oxygen species
aging
Online Access:https://www.mdpi.com/2076-3921/8/6/168

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https://www.mdpi.com/2076-3921/8/6/168

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