Extracellular Vesicle-Derived microRNAs of Human Wharton’s Jelly Mesenchymal Stromal Cells May Activate Endogenous VEGF-A to Promote Angiogenesis

Extracellular Vesicle-Derived microRNAs of Human Wharton’s Jelly Mesenchymal Stromal Cells May Activate Endogenous VEGF-A to Promote Angiogenesis

Despite low levels of vascular endothelial growth factor (VEGF)-A, the secretome of human Wharton’s jelly (WJ) mesenchymal stromal cells (MSCs) effectively promoted proangiogenic responses in vitro, which were impaired upon the depletion of small (~140 nm) extracellular vesicles (EVs). The isolated...

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Bibliographic Details
Main Authors: Cinzia Maria Chinnici, Gioacchin Iannolo, Ettore Cittadini, Anna Paola Carreca, David Nascari, Francesca Timoneri, Mariangela Di Bella, Nicola Cuscino, Giandomenico Amico, Claudia Carcione, Pier Giulio Conaldi
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Wharton’s jelly
mesenchymal stromal cells
extracellular vesicles
microRNAs
<i>VEGF-A</i> and <i>THBS1</i> target genes
in vitro angiogenesis
Online Access:https://www.mdpi.com/1422-0067/22/4/2045

Internet

https://www.mdpi.com/1422-0067/22/4/2045

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