Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine

Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine

Abstract Background High grade serous ovarian cancer (HGSOC) is among the deadliest human cancers and its prognosis remains extremely poor. Tumor heterogeneity and rapid acquisition of resistance to conventional chemotherapeutic approaches strongly contribute to poor outcome of patients. The clinica...

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Bibliographic Details
Main Authors: Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia, Claudio Sette
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ovarian cancer
Organoids
Target therapy
3D cultures
Drug screening
Online Access:https://doi.org/10.1186/s13046-021-01917-7

Internet

https://doi.org/10.1186/s13046-021-01917-7

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