Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Abstract Background Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no attempt to neutralize IGF2 has been r...

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Bibliographic Details
Main Authors: Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
IGF2
Immunoprevention
Rhabdomyosarcoma
IGF1R
DNA vaccines
Neutralizing antibodies
Online Access:http://link.springer.com/article/10.1186/s12885-019-5339-4

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http://link.springer.com/article/10.1186/s12885-019-5339-4

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