The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

<p>Abstract</p> <p>Background</p> <p>The accumulation of amyloid beta (Aβ) oligomers or fibrils is thought to be one of the main causes of synaptic and neuron loss, believed to underlie cognitive dysfunction in Alzheimer’s disease (AD). Neuron loss has rarely been docum...

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Bibliographic Details
Main Authors: Brautigam Hannah, Steele John W, Westaway David, Fraser Paul E, George-Hyslop Peter H St, Gandy Sam, Hof Patrick R, Dickstein Dara L
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Mouse models
Amyloid beta (Aβ)
Isotropic fractionator
Neuronal loss
Online Access:http://www.molecularneurodegeneration.com/content/7/1/58

Internet

http://www.molecularneurodegeneration.com/content/7/1/58

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