Structural Basis of Homology-Directed DNA Repair Mediated by RAD52

Structural Basis of Homology-Directed DNA Repair Mediated by RAD52

Summary: RAD52 mediates homologous recombination by annealing cDNA strands. However, the detailed mechanism of DNA annealing promoted by RAD52 has remained elusive. Here we report two crystal structures of human RAD52 single-stranded DNA (ssDNA) complexes that probably represent key reaction interme...

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Bibliographic Details
Main Authors: Mika Saotome, Kengo Saito, Takeshi Yasuda, Hideaki Ohtomo, Shusei Sugiyama, Yoshifumi Nishimura, Hitoshi Kurumizaka, Wataru Kagawa
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300373

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http://www.sciencedirect.com/science/article/pii/S2589004218300373

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