Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the DNA-damaging effect of the cytotoxic drugs, can mediate therapeutic resistance to chemotherapy. The monofunctional DNA...

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Bibliographic Details
Main Authors: Koji eYoshimoto, Masahiro eMizoguchi, Nobuhiro eHata, Hideaki eMurata, Ryusuke eHatae, Toshiyuki eAmano, Akira eNakamizo, Tomio eSasaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Oncology
Subjects:
chemoresistance
TMZ.
DNA repair.
PARP.
Homologous recombination.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00186/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00186/full

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