The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling

The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling

Abstract In Drosophila, precise regulation of BMP signaling is essential for normal synaptic growth at the larval neuromuscular junction (NMJ) and neuronal survival in the adult brain. However, the molecular mechanisms underlying fine-tuning of BMP signaling in neurons remain poorly understood. We s...

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Bibliographic Details
Main Authors: Keunjung Heo, Minyeop Nahm, Min-Jung Lee, Young-Eun Kim, Chang-Seok Ki, Seung Hyun Kim, Seungbok Lee
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Molecular Brain
Subjects:
Drosophila
Gef26
Synaptic growth
Neurodegeneration
Endocytic regulation of BMP signaling
Online Access:http://link.springer.com/article/10.1186/s13041-017-0342-7

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http://link.springer.com/article/10.1186/s13041-017-0342-7

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