System wide cofactor turnovers can propagate metabolic stability between pathways

Metabolic homeostasis, or low-level metabolic steady state, has long been taken for granted in metabolic engineering, and research priority has always been given to understand metabolic flux control and regulation of the reaction network. In the past, this has not caused concerns because the metabol...

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Bibliographic Details
Main Authors: Y. Yang, Y.H. Guan, J. Villadsen
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Metabolic Engineering Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030116300190