Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

4E-BP1 is a translational repressor critical in mTOR signaling, whereas Snail is a critical promoter of epithelial to mesenchymal transition. Here the authors show that Snail induces resistance to mTOR inhibitors by repressing 4E-BP1 expression and promoting cell cycle progression via upregulating c...

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Bibliographic Details
Main Authors: Jun Wang, Qing Ye, Yanan Cao, Yubin Guo, Xiuping Huang, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Mark Evers, Qing-Bai She
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02243-3

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https://doi.org/10.1038/s41467-017-02243-3

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